GUM® Chlorhexidine Gluconate Oral Rinse USP, 0.12% is indicated for use between dental visits as part of a professional program for the treatment of gingivitis. This oral rinse should not be used by persons who are known to be hypersensitive to Chlorhexidine Gluconate. The effect of Chlorhexidine Gluconate Oral Rinse USP, 0.12% on periodontitis has not yet been determined. Chlorhexidine Gluconate Oral Rinse can cause staining of oral surfaces, increase calculus formation and cause taste interference. Please see all prescribing information available with the product or on-line at www.GUMbrand.com.
1. Lang et al. Plaque formation and gingivitis after supervised mouthrinsing with 0.2% delmopinol hydrochloride, 0.2% chlorhexidine digluconate and placebo for 6 months. Oral Diseases 1998;4:105-113. 2. Addy et al. Meta-analyses of studies of 0.2% delmopinol mouth rinse as an adjunct to gingival health and plaque control measures. J Clin Periodontol 2007;34:58-65. 3. Hase et al. 6-month use of 0.2% delmopinol hydrochloride in comparison with 0.2% chlorhexidine digluconate and placebo. (I) Effect on plaque formation and gingivitis. J Clin Periodontol 1998;25:746-753.
4. Claydon et al. A 6-month home usage trial of 0.1% and 0.2% delmopinol mouthwashes. (I) Effects on plaque, gingivitis, supragingival calculus and tooth staining. J Clin Periodontol 1996;23:220-228. 5. Rundegren et al. Effect of delmopinol on the viscosity of extracellular glucans produced by Streptococcus mutans. Caries Res 1992;26:281-285. 6. Steinberg et al. The effect of delmopinol on glucosyltransferase adsorbed on to saliva-coated hydroxyapatite. Archs Oral Biol 1992 (37);1:33-38. 7. Klinge et al. Effect of local application of delmopinol hydrochloride on developing and early established supragingival plaque in humans. J Clin Periodontol 1996;23:543-547. 8. Rundegren et al. Delmopinol interactions with cell walls of gram-negative and gram-positive oral bacteria. Oral Microbiol Immunol 1995;10:102-109. 9. Data on file. *Study for safety and efficacy available for up to one year. 10. Plaque Index 2-3 on a scale from 0, for no plaque, to 3, for abundance of soft matter within gingival pocket and tooth surface. 11. Krasse et al. Decreased gum bleeding and reduced gingivitis by probiotic Lactobacillus reuteri. Swed Dent J 2006; 30: 55-60. 12. Data on file. Note 28 day results from uncontrolled extension of the 14-day clinical study as referenced in footnote 2.
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